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Table 1. Potential pairings
for SMART domains at fold and superfamily level |
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SCOP fold |
N |
SMART domains |
SCOP fold |
N |
SMART domains |
SCOP fold |
N |
SMART domains |
|
Knottins |
10 |
e-FOLN, e-EGF_CA,
e-EGF_Lam, e-FU, e-IB, e-PTI, e-fCBD, e-ChtBD, e-WAP, e-BowB |
DNA/RNA-binding
3-helical bundle |
9 |
n-HTH_ARSR, n-ETS, n-FH,
n-HTH_CRP, n-IRF, n-HSF, n-SANT, n-HOX, n-PAX |
Immunoglobulin fold |
7 |
e-IGc1, e-IGc2, e-IGv,
n-IPT, e-PKD, e-CA, e-FN3 |
|
OB fold |
4 |
n-CSP, o-S1, o-SNc,
e-TIMP, |
SAM domain-like |
4 |
n-HhH2, n-HhH1, o-SAM_PNT,
s-SAM |
b trefoil |
4 |
e-IL1, e-FGF, e-RICIN,
e-STI |
|
b-grasp |
3 |
s-RBD, s-RA, s-UBQ |
Long a-hairpin |
2 |
o-DnaJ, s-HR1 |
IL8-like |
2 |
e-SCY,
n-CHROMO |
|
Four helical bundle |
2 |
s-HPT, s-TarH |
Leucine-rich repeat |
2 |
o-LRRcap, e-LRR_RI |
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SCOP superfamily |
N |
SMART domains |
SCOP superfamily |
N |
SMART domains |
SCOP superfamily |
N |
SMART domains |
|
P-loop
containing nucleotide hydrolases |
11 |
s-MYSc, o-AAA, s-RAN, s-RAB, s-SAR,
s-RAS, s-RHO, s-ARF, s-G-alpha, s-GuKc, s-KISc |
Four helical cytokines |
7 |
e-IL4_13, e-IL10, e-IFabd, e-CSF2, e-IL2,
e-LIF_OSM, e-IL6 |
Winged helix DNA-binding domain |
6 |
n-HTH_ARSR, n-ETS, n-FH, n-HTH_CRP, n-IRF,
n-HSF |
|
Immunoglobulin |
5 |
e-IGc1, e-IGc2, e-IGv, n-IPT, e-PKD |
Nucleosome core histones |
5 |
n-H3, n-H2A, n-H4, n-H2B, n-AHL |
PH domain-like |
5 |
s-PTB, s-RanBD, s-WH1, s-PH, s-BTK |
|
Cystine-knot cytokines |
4 |
e-GHA, e-PDGF, e-TGFB, e-NGF |
Homeodomain-like |
3 |
n-SANT, n-HOX, n-PAX |
DEATH domain |
3 |
s-DED, s-DEATH, s-CARD |
|
Periplasmic binding protein-like II |
3 |
e-PBPb, e-PBPe, e-TR_FER |
Protein tyrosine phosphatase I-like |
3 |
s-PTPc, s-DSPc, o-RHOD |
EGF/Laminin |
3 |
e-EGF_CA, e-FOLN, e-EGF_Lam |
|
GTPase activation domain (GAP) |
2 |
s-RasGAP, s-RhoGAP |
l repressor-like DNA binding dom. |
2 |
n-POU, n-HTH_LACI |
Actin
de-polarizing proteins |
2 |
e-GEL,
s-ADF |
|
EF Hand-like |
2 |
s-EH, s-Efh |
SAM/pointed dom. |
2 |
o-SAM_PNT, s-SAM |
ATPase
dom. HSP90/ topoisomerase II/ his kinase |
2 |
s-HATPase_c,
n-TOP2c |
|
5'-3' exonuclease, C-term dom. |
2 |
n-HhH2, n-HhH1 |
TNF-like |
2 |
e-C1Q, e-TNF |
IGF
binding dom. |
2 |
e-IB,
e-FU |
|
ConA-like lectins |
2 |
e-PTX, e-GLECT, e-LamG |
Cold
shock protein |
2 |
n-CSP,
o-S1 |
Ser/Thr
phosphatase 2C |
2 |
s-PP2Cc,
o-PP2C_SIG |
| C-type
lectin |
2 |
e-LINK,
e-CLECT |
Kringle-like |
2 |
e-KR,
e-FN2 |
Ras-binding dom. |
2 |
s-RBD, s-RA |
| DNA
binding dom |
2 |
n-MBD,
n-AP2 |
Glucocorticoid
receptor-like |
2 |
n-ZnF_GATA,
n-ZnF_C4 |
b trefoil cytokines |
2 |
e-IL1,
e-FGF |