SCOP Superfamily

Pfam i

Ni  Seqs 

Di

Pfam j

Nj  Seqs 

Dj

P3D

MP3D

 Identities 

N eq  residues 

Link i

Link j

Class II aaRS and biotin synthetases

tRNA-synt_2

118

11.83

tRNA-synt_2d

51

8.578

1.11E-11

1.13E-09

39

120

SYF_METJA

SYK_THETH

Periplasmic binding protein-like II

SBP_bac_3

96

15.96

lig_chan

168

7.97

9.89E-12

1.26E-09

44

146

1gr2a_

GLNH_ECOLI

Glutathione synthetase ATP-binding domain-like

Dala_Dala_ligas

136

6.008

CPSase_L_chain

208

8.385

6.96E-11

3.51E-09

42

143

DDL_TREPA

BCCA_MYCTU

Phosphatase/sulphatase

Sulfatase

60

16.87

alk_phosphatase

65

6.709

1.62E-10

1.83E-08

41

141

PPB_SERMA

ARS_HEMPU

Thiolase-like

thiolase

148

9.557

ketoacyl-synt

348

11.05

1.62E-09

1.71E-07

30

91

ERY2_SACER

THIL_THIVI

Thiolase-like

Chal_stil_synt

225

2.472

thiolase

148

9.557

9.95E-09

2.35E-07

28

87

NLTP_RAT

CHSY_ANTMA

P-loop containing nucleotide triphosphate hydrolases

arf

140

4.887

G-alpha

297

5.712

4.49E-08

1.25E-06

32

115

GBA1_COPCO

ARF3_DROME

P-loop containing nucleotide triphosphate hydrolases

Adenylsucc_synt

12

4.508

SRP54

128

8.144

7.99E-08

2.93E-06

28

95

1dj3a

PILA_NEIGO/147-415

P-loop containing nucleotide triphosphate hydrolases

fer4_NifH

546

3.688

SRP54

128

8.144

1.89E-07

5.68E-06

31

116

BCHX_RHOSH

SRPR_YEAST

alpha/beta-Hydrolases

Peptidase_S9

85

7.898

COesterase

410

13.62

5.44E-08

5.85E-06

19

48

DAP2_YEAST

BAL_HUMAN

PLP-dependent transferases

aminotran_1

310

13.68

Cys_Met_Meta_PP

88

8.039

5.85E-08

6.43E-06

39

158

CYSD_EMENI

ATTY_RHIME

beta-Lactamase/D-ala carboxypeptidase

Peptidase_S11

35

8.998

beta-lactamase

235

9.515

8.30E-08

7.11E-06

39

160

PBP5_PSEAE

BLAC_NOCLA

ATPase domain of HSP9

HSP90

162

5.646

DNA_mis_repair

46

11.29

1.15E-07

7.33E-06

27

91

1ah8b_

1b62a2

Single hybrid motif

biotin_lipoyl

264

11.07

GCV_H

49

4.039

1.66E-07

7.42E-06

19

51

P73560

ODP2_ECOLI

P-loop containing nucleotide triphosphate hydrolases

recA

235

2.294

Guanylate_kin

97

8.338

4.41E-07

8.44E-06

18

49

1gky__

RECA_ANAVA

P-loop containing nucleotide triphosphate hydrolases

SRP54

128

8.144

GTP_EFTU

1207

9.799

1.11E-07

8.86E-06

25

80

TYPA_ECOLI

SR54_ECOLI

Ferritin-like

ferritin

109

5.866

Bacteriofer

9

3.352

7.88E-07

1.55E-05

34

142

BFR_BRUME/1-154

FRI3_RANCA/13-169

FAD/NAD(P)-binding domain

GMC_oxred

68

10.86

GDI

43

4.815

3.08E-07

1.61E-05

25

84

ALOX_CANBO

O22402

ETFP adenine nucleotide-binding domain-like

ETF_beta

30

7.508

ETF_alpha

31

6.908

4.88E-07

2.53E-05

33

133

O29954

ETFB_HUMAN

Winged helix DNA-binding domain

histone

536

6.564

CBFD_NFYB_HMF

70

5.916

8.61E-07

3.34E-05

19

56

HJA1_METJA

H2A1_HUMAN

Winged helix DNA-binding domain

histone

536

6.564

CBFD_NFYB_HMF

70

5.916

8.61E-07

3.34E-05

19

56

HJA1_METJA

H2A1_HUMAN

lambda repressor-like DNA-binding domains

lacI

109

4.273

HTH_3

291

19.27

4.24E-07

3.49E-05

12

23

ASCG_ECOLI

O21993

Thioredoxin-like

Calsequestrin

12

2.016

thiored

475

12.78

1.81E-06

4.66E-05

24

86

CAQC_CANFA

PDI_CHICK

NAD(P)-binding Rossmann-fold domains

GLFV_dehydrog

109

9.142

2-Hacid_DH

18

8.652

5.97E-07

4.72E-05

28

104

DHGY_HYPME/78-287

DHE3_PYRFU/34-416

Lysozyme-like

lys

142

4.19

SLT

71

14.55

8.62E-07

5.26E-05

18

51

O67519

LYC1_CAPHI

P-loop containing nucleotide triphosphate hydrolases

G-alpha

297

5.712

ras

803

8.533

1.09E-06

5.31E-05

28

107

GB12_HUMAN

ARA3_ARATH

Snake toxin-like

toxin

308

5.92

UPAR_LY6

52

8.394

1.08E-06

5.37E-05

16

42

LY6A_MOUSE

CX10_NAJHA

Snake toxin-like

toxin

308

5.92

UPAR_LY6

52

8.394

1.08E-06

5.37E-05

16

42

LY6A_MOUSE

CX10_NAJHA

Snake toxin-like

toxin

308

5.92

UPAR_LY6

52

8.394

1.08E-06

5.37E-05

16

42

LY6A_MOUSE

CX10_NAJHA

Actin-like ATPase domain

HSP70

526

4.008

actin

597

3.03

4.76E-06

5.78E-05

28

115

ACT7_ORYSA

DNAK_BORBU

NAD(P)-binding Rossmann-fold domains

GLFV_dehydrog

109

9.142

IlvC

40

5.07

2.23E-06

0.00010336

17

49

ILVC_SYNY3

DHE4_HALSA

POZ domain

Skp1

26

8.154

BTB

121

18.46

7.77E-07

0.00011702

21

66

O16313/48-165

Q15369/17-112

Cystine-knot cytokines

Cys_knot

154

9.243

hormone6

41

1.821

7.74E-06

0.00013028

16

48

GLHA_HORSE

GTH1_FUNHE

Acid proteases

rvp

2929

2.478

asp

290

12.08

5.07E-06

0.00015177

26

103

1hvc__

CARP_SACFI

Nucleic acid-binding proteins

CSD

210

5.598

S1

363

16.54

2.01E-06

0.00018611

15

39

CSPH_ECOLI

IF1_MYCSP

PLP-binding barrel

Ala_racemase

9

6.686

UPF0001

7

6.306

4.42E-06

0.00018619

32

140

ALR_SYNY3/59-400

YGGS_ECOLI/6-230

P-loop containing nucleotide triphosphate hydrolases

ras

803

8.533

GTP_EFTU

1207

9.799

2.37E-06

0.00019817

27

105

HBS1_YEAST

RAB5_TOBAC

NAD(P)-binding Rossmann-fold domains

THF_DHG_CYH

46

5.288

2-Hacid_DH

18

8.652

5.14E-06

0.00023516

25

97

DHD2_LACCA/78-295

FOLD_MYCGE/6-262

P-loop containing nucleotide triphosphate hydrolases

fer4_NifH

546

3.688

ras

803

8.533

7.58E-06

0.00023854

23

87

RB18_LYMST

BCHX_RHOSH

P-loop containing nucleotide triphosphate hydrolases

arf

140

4.887

GTP_EFTU

1207

9.799

5.14E-06

0.00024614

24

91

EFTU_COLOB

ARFL_CAEEL

ClpP/crotonase

ECH

193

12.72

CLP_protease

79

5.948

3.48E-06

0.00026329

25

95

CLPP_BACSU

ECHP_HUMAN

Winged helix DNA-binding domain

LexA_DNA_bind

18

3.916

trans_reg_C

262

9.048

7.71E-06

0.00027318

14

38

YC27_CYAPA

LEXA_AERHY

beta-Lactamase/D-ala carboxypeptidase

Peptidase_S11

35

8.998

Transpeptidase

307

13.25

2.33E-06

0.00027779

28

111

PBP3_ECOLI

PBP7_ECOLI

NAD(P)-binding Rossmann-fold domains

adh_zinc

45

13.65

2-Hacid_DH

18

8.652

2.47E-06

0.00029206

20

65

DHD2_LACCA/78-295

YJJN_ECOLI/10-344

P-loop containing nucleotide triphosphate hydrolases

arf

140

4.887

SRP54

128

8.144

8.34E-06

0.00033193

20

70

ARF1_YEAST

SR51_ARATH

FMN-linked oxidoreductases

FMN_dh

45

7.132

oxidored_FMN

60

10.14

4.74E-06

0.00034279

31

134

1gyla_

BAIH_EUBSP

Thiamin diphosphate-binding fold (THDP-binding)

transketolase

87

6.031

TPP_enzymes

165

13.78

4.13E-06

0.00034323

27

108

ILVI_ECOLI

TKTC_ALCEU

NAD(P)-binding Rossmann-fold domains

GLFV_dehydrog

109

9.142

THF_DHG_CYH

46

5.288

7.43E-06

0.00035919

22

81

MTDC_HUMAN

DHE2_CLODI

P-loop containing nucleotide triphosphate hydrolases

adenylatekinase

143

6.163

recA

235

2.294

2.63E-05

0.00037183

17

58

1ak2_1

RECA_STRPN

Nucleotidylyl transferase

tRNA-synt_1

178

17.31

tRNA-synt_1c

92

10.9

2.07E-06

0.00039057

36

161

SYQ_HAEIN

SYV_BACSU

Scorpion toxin-like

Gamma-thionin

63

4.999

toxin_2

27

3.744

2.91E-05

0.00054464

10

23

P322_SOLTU

SCKC_LEIQH

NAD(P)-binding Rossmann-fold domains

3HCDH

87

9.522

THF_DHG_CYH

46

5.288

1.25E-05

0.0006294

17

55

C1TM_YEAST

HCD2_CAEEL

Winged helix DNA-binding domain

Fork_head

227

3.825

linker_histone

186

5.904

2.84E-05

0.00064135

13

37

FKH2_YEAST

H1A_PLADU

NAD(P)-binding Rossmann-fold domains

3HCDH

87

9.522

IlvC

40

5.07

1.33E-05

0.00064208

24

96

ILVC_CORGL

HCD1_CAEEL

TNF-like

TNF

84

8.497

C1q

39

5.662

1.35E-05

0.00064949

21

78

CD3L_MOUSE

C1QC_HUMAN

P-loop containing nucleotide triphosphate hydrolases

adenylatekinase

143

6.163

ras

803

8.533

1.30E-05

0.00068366

12

30

KAD_STRCO

RAS1_PHYPO

Thioredoxin-like

DSBA

21

5

thiored

475

12.78

1.11E-05

0.00070929

18

60

Q04815

THIO_STRAU

P-loop containing nucleotide triphosphate hydrolases

recA

235

2.294

fer4_NifH

546

3.688

9.75E-05

0.00082488

17

64

1rea_1

BCHL_RHOCA

Snake toxin-like

UPAR_LY6

52

8.394

Activin_recp

26

11.41

8.66E-06

0.00082894

12

29

O42475/33-108

THYB_MOUSE/1-126

P-loop containing nucleotide triphosphate hydrolases

recA

235

2.294

SRP54

128

8.144

4.89E-05

0.00091357

16

55

RECA_RICPR

SR51_ARATH

Winged helix DNA-binding domain

LexA_DNA_bind

18

3.916

HTH_5

100

13.11

1.95E-05

0.00100111

15

46

HLYU_VIBCH

LEXA_BACSU

S-adenosyl-L-methionine-dependent methyltransferases

RrnaAD

120

9.65

Methyltransf_3

54

4.74

2.34E-05

0.00107034

23

93

1vid__

DIM1_YEAST

beta-Lactamase/D-ala carboxypeptidase

beta-lactamase

235

9.515

Transpeptidase

307

13.25

8.69E-06

0.00109558

29

125

P71586

BLAT_ECOLI

Nucleotidylyl transferase

tRNA-synt_1b

96

12.53

Cytidylyltransf

97

14.55

6.62E-06

0.0012069

20

69

SYY_HAEIN

O58466

P-loop containing nucleotide triphosphate hydrolases

G-alpha

297

5.712

GTP_EFTU

1207

9.799

2.51E-05

0.00140489

25

106

EF1A_SULAC

GBA7_DICDI

Thioredoxin-like

AhpC-TSA

27

10.85

GSHPx

83

4.06

3.31E-05

0.00145897

23

95

1gp1a

BCP_HAEIN/6-149

Kringle-like

kringle

276

4.502

fn2

122

3.724

9.42E-05

0.00157931

8

17

FA12_HUMAN

HGF_HUMAN

P-loop containing nucleotide triphosphate hydrolases

SRP54

128

8.144

ras

803

8.533

2.38E-05

0.00165393

19

69

RALA_HUMAN

SR54_MYCMY

P-loop containing nucleotide triphosphate hydrolases

adenylatekinase

143

6.163

Guanylate_kin

97

8.338

3.88E-05

0.00199382

12

33

KGUA_BOVIN

KAD_BACSU

P-loop containing nucleotide triphosphate hydrolases

G-alpha

297

5.712

SRP54

128

8.144

4.39E-05

0.00204216

20

78

GBA8_DICDI

SR5C_ARATH

Tautomerase/MIF

Tautomerase

14

4.449

MIF

20

4.885

9.98E-05

0.00216899

12

36

1otff_

DOPD_RAT

NAD(P)-binding Rossmann-fold domains

3HCDH

87

9.522

GLFV_dehydrog

109

9.142

2.58E-05

0.00224589

15

47

DHE2_CLODI

MMGB_BACSU

PH domain-like

WH1

48

5.725

Ran_BP1

51

6.29

6.82E-05

0.0024559

22

93

1evha_

N358_HUMAN

HIT-like

GalP_UDP_transf

39

7.532

HIT

57

9.112

3.62E-05

0.00248446

19

71

GAL7_YEAST

PKIA_DICDI

NAD(P)-binding Rossmann-fold domains

GLFV_dehydrog

109

9.142

malic

122

6.317

5.29E-05

0.00305498

20

79

DHE4_CORGL

MAON_SOLTU

Thioredoxin-like

DSBA

21

5

glutaredoxin

63

10.09

6.37E-05

0.00321367

14

45

1jhb__

DSBA_ERWCH

CoA-dependent acyltransferases

CAT

31

3.967

2-oxoacid_dh

98

7.633

1.17E-04

0.00354277

28

137

ODP2_AZOVI

CAT2_ECOLI

NAD(P)-binding Rossmann-fold domains

IlvC

40

5.07

GFO_IDH_MocA

108

21.14

3.52E-05

0.00377273

18

65

ILVC_CORGL

O23580

NAD(P)-binding Rossmann-fold domains

IlvC

40

5.07

DapB

27

6.555

1.14E-04

0.00378866

15

53

ILVC_CORGL

DAPB_ECOLI

P-loop containing nucleotide triphosphate hydrolases

fer4_NifH

546

3.688

TK_herpes

77

6.72

1.74E-04

0.0043123

17

67

1ki2b_

NIF1_CLOPA

Glycosyltransferases

Glyco_hydro_17

134

5.341

Glyco_hydro_2

47

8.302

1.00E-04

0.0044341

26

122

E13F_HORVU

BGAL_KLEPN

NAD(P)-binding Rossmann-fold domains

IlvC

40

5.07

THF_DHG_CYH

46

5.288

1.69E-04

0.00453092

14

49

MTDC_HUMAN

ILVC_ECOLI

FAD/NAD(P)-binding domain

GMC_oxred

68

10.86

pyr_redox

447

18.96

2.24E-05

0.00461229

24

99

BETA_ECOLI

GSHR_ECOLI

Periplasmic binding protein-like II

Porphobil_deam

53

5.989

transferrin

174

6.102

1.33E-04

0.00486047

12

37

HEM3_CLOJO

TRFE_HORSE

P-loop containing nucleotide triphosphate hydrolases

adenylatekinase

143

6.163

TK_herpes

77

6.72

1.19E-04

0.00492843

17

65

KITH_HSVBH

KAD_PARDE

S-adenosyl-L-methionine-dependent methyltransferases

CheR

31

8.951

Methyltransf_3

54

4.74

1.28E-04

0.00543075

22

97

CHER_ECOLI

CAMT_EUCGU

Di-copper centre-containing domain

tyrosinase

114

10.1

hemocyanin

165

11.11

4.89E-05

0.00548712

22

91

1nol_2

TYR2_HUMAN

Nucleotidylyl transferase

tRNA-synt_1b

96

12.53

tRNA-synt_1c

92

10.9

4.12E-05

0.00562697

22

90

Q49900

SYE_AZOBR

Glyceraldehyde-3-phosphate dehydrogenase-like,C-terminal domain

gpdh

399

4.869

Semialdhyde_dh

92

10.34

1.17E-04

0.00589042

18

71

O32353

G3P1_TRIKO

P-loop containing nucleotide triphosphate hydrolases

adenylatekinase

143

6.163

SRP54

128

8.144

1.19E-04

0.00597279

17

65

KADA_ORYSA

SRPR_CANFA

Defensin-like

Defensin_beta

34

3.301

defensins

50

3.85

5.17E-04

0.00657048

8

21

BD04_BOVIN

DEF2_RABIT

p53-like transcription factors

STAT

51

4.404

RHD

59

4.951

3.21E-04

0.00699915

15

58

Q14765

RELB_HUMAN

alpha/beta-Hydrolases

Lipase_3

42

11.92

COesterase

410

13.62

4.38E-05

0.00711095

15

49

O49523

NRT_DROME

Xylose isomerase-like

Xylose_isom

12

3.824

AP_endonulease2

8

10.75

1.74E-04

0.00716512

32

169

END_MYCLE/7-252

XYLA_THETH/6-383

Thioredoxin-like

thiored

51

12.78

AhpC-TSA

27

10.85

6.16E-05

0.00853609

16

56

TSA1_YEAST/4-153

THIH_ARATH/6-114

FAD/NAD(P)-binding domain

GDI

43

4.815

FAD_binding_3

75

13.67

1.30E-04

0.00855674

26

124

1cj2a1

O02441

4-helical cytokines

EPO_TPO

21

2.689

GM_CSF

10

1.956

1.74E-03

0.00915185

13

55

CSF2_PIG

EPO_MOUSE

DEATH domain

CARD

61

10.35

DED

57

6.602

1.34E-04

0.00915631

14

48

O35707

RAID_HUMAN

S-adenosyl-L-methionine-dependent methyltransferases

RrnaAD

120

9.65

DNA_methylase

263

14.43

7.24E-05

0.01008166

21

87

MTNM_NEIGO

ERM1_STAAU

NAD(P)-binding Rossmann-fold domains

malic

122

6.317

IlvC

40

5.07

3.21E-04

0.01028073

15

58

ILVC_SYNY3

MAO2_BACSU

lambda repressor-like DNA-binding domains

pou

168

2.156

HTH_3

291

19.27

2.54E-04

0.01055271

11

34

RDGA_ERWCA

HMP1_BOVIN

4-helical cytokines

IL-6

10

4.675

LIF_OSM

11

2.983

8.10E-04

0.01129588

19

90

ONCM_HUMAN

CSF3_BOVIN

Glycosyltransferases

cellulase

156

20.92

Glyco_hydro_2

47

8.302

7.29E-05

0.01266111

25

113

GUNB_CLOTM

BGAL_KLULA

Cystine-knot cytokines

Cys_knot

154

9.243

TGF-beta

277

6.04

2.27E-04

0.01267289

12

39

BMP8_HUMAN

CTGF_HUMAN

NAD(P)-binding Rossmann-fold domains

GLFV_dehydrog

109

9.142

DapB

27

6.555

2.15E-04

0.01288405

16

62

DHE4_HALSA

DAPB_MYCBO

Aldolase

DHDPS

15

10.58

ALAD

10

4.234

3.00E-04

0.01345663

27

138

HEM2_BACSU/17-315

NPL_ECOLI/24-276

alpha/beta-Hydrolases

DLH

56

14.28

Lipase_3

42

11.92

7.99E-05

0.01360039

18

69

LIP_RHIMI

TCBE_PSESP

alpha/beta-Hydrolases

COesterase

410

13.62

serine_carbpept

142

12.55

7.98E-05

0.01364029

24

107

SXA2_SCHPO

ESTE_MYZPE

P-loop containing nucleotide triphosphate hydrolases

arf

140

4.887

recA

235

2.294

1.22E-03

0.01367715

9

29

RECA_ACICA

SARA_MOUSE

P-loop containing nucleotide triphosphate hydrolases

arf

140

4.887

ras

803

8.533

3.33E-04

0.01388636

11

35

ARD1_RAT

YPT8_YEAST

Winged helix DNA-binding domain

HTH_5

100

13.11

trans_reg_C

262

9.048

1.20E-04

0.01423431

13

42

1smta_

AFQ1_STRCO

S-adenosyl-L-methionine-dependent methyltransferases

Methyltransf_3

54

4.74

DNA_methylase

263

14.43

2.09E-04

0.01429522

17

68

O67476

MTNM_NEIGO

PLP-dependent transferases

Cys_Met_Meta_PP

88

8.039

aminotran_5

140

19.29

1.04E-04

0.01612752

30

150

CYS3_YEAST

SERC_RABIT

4-helical cytokines

interferon

110

4.537

GM_CSF

10

1.956

1.87E-03

0.01659508

12

49

CSF2_CANFA

INA1_MOUSE

Glutathione synthetase ATP-binding domain-like

Dala_Dala_ligas

136

6.008

PPDK_N_term

53

7.572

3.81E-04

0.01733267

21

98

P95114

O05566

ETFP adenine nucleotide-binding domain-like

Usp

75

17.03

ETF_beta

30

7.508

1.42E-04

0.0181563

15

54

USPA_ECOLI

ETFB_CLOTS

alpha/beta-Hydrolases

DLH

56

14.28

COesterase

410

13.62

9.39E-05

0.01826295

22

95

O86353

SASB_ANAPL

Six-hairpin glycosyltransferases

Glyco_hydro_15

19

4.584

Glyco_hydro_9

155

8.205

4.86E-04

0.0182793

25

128

AMYG_RHIOR

GUN1_PERAE

Trypsin-like serine proteases

trypsin

1239

13.32

Flavi_helicase

83

2.277

6.14E-04

0.0186224

16

68

O09234

STSP_STAAU

P-loop containing nucleotide triphosphate hydrolases

kinesin

314

7.939

arf

140

4.887

4.85E-04

0.01881698

10

31

FL10_CHLRE

ARL1_DROME

S-adenosyl-L-methionine-dependent methyltransferases

RrnaAD

120

9.65

CheR

31

8.951

2.20E-04

0.01900297

19

81

Q53129

ERMA_CORDI

4-helical cytokines

IL4

25

3.035

GM_CSF

10

1.956

3.55E-03

0.02107443

12

53

IL4_PIG

CSF2_PIG

PLP-dependent transferases

aminotran_3

213

11.85

aminotran_5

140

19.29

9.23E-05

0.02109853

29

142

OAT_ECOLI

NIFS_BACSU

P-loop containing nucleotide triphosphate hydrolases

Guanylate_kin

97

8.338

SRP54

128

8.144

3.11E-04

0.02111835

16

64

1gky__

SR5C_ARATH

PLP-dependent transferases

aminotran_3

213

11.85

Beta_elim_lyase

15

2.951

6.05E-04

0.02115646

28

152

GATA_EMENI

TNAA_ENTAE

Cytokine

interleukin-1

12

6.054

FGF

110

6.125

5.98E-04

0.02217429

18

81

IL1B_BOVIN

FGF6_HUMAN

Enolase C-terminal domain-like

MR_MLE

59

10.37

enolase

139

3.031

7.47E-04

0.02347931

25

132

ENOA_ANAPL

MANR_PSEPU

P-loop containing nucleotide triphosphate hydrolases

recA

235

2.294

UvrD-helicase

89

13.46

7.63E-04

0.02355933

17

76

RECA_ANAVA

REP_HAEIN

ConA-like lectins/glucanases

Glyco_hydro_11

96

4.362

Glyco_hydro_12

22

5.836

1.05E-03

0.02672946

19

92

O00095

XYN1_COCCA

ConA-like lectins/glucanases

lectin_legB

158

6.141

Glyco_hydro_7

33

3.222

1.36E-03

0.02690937

14

60

GUNC_FUSOX

LEC_ONOVI

Periplasmic binding protein-like II

Sulphate_bind

10

3.949

PstS

43

10.64

6.73E-04

0.02827768

25

131

O05870

SUBI_ECOLI

NAD(P)-binding Rossmann-fold domains

3HCDH

87

9.522

GFO_IDH_MocA

108

21.14

1.42E-04

0.0285839

15

54

YJHC_STRPN

HCDH_PIG

Glycosyltransferases

Glyco_hydro_10

138

8.85

Glyco_hydro_2

47

8.302

4.06E-04

0.02982992

19

85

XYNA_PSEFL

BGLR_ECOLI

alpha/beta-Hydrolases

DLH

56

14.28

serine_carbpept

142

12.55

1.67E-04

0.02992874

26

126

CBP2_WHEAT

O86353

P-loop containing nucleotide triphosphate hydrolases

TK_herpes

77

6.72

SRP54

128

8.144

5.85E-04

0.03201569

12

43

KITH_HSV11

FTSY_ECOLI

NAD(P)-binding Rossmann-fold domains

3HCDH

87

9.522

3Beta_HSD

45

6.532

5.21E-04

0.032405

16

67

HBD_CLOAB

Q67477

Phosphoglycerate mutase-like

PGAM

164

10.14

acid_phosphat

164

10.17

3.27E-04

0.03372148

18

77

PHYB_ASPAW

PMGE_HUMAN

NAD(P)-binding Rossmann-fold domains

malic

122

6.317

DapB

27

6.555

8.29E-04

0.03432718

14

57

DAPB_MYCBO

MAOX_YEAST

C-type lectin-like

lectin_c

692

19.95

Xlink

103

4.581

3.79E-04

0.03463717

9

25

NK13_RAT

PGCB_FELCA

NAD(P)-binding Rossmann-fold domains

malic

122

6.317

THF_DHG_CYH

46

5.288

1.04E-03

0.03474047

18

85

Q55626

MAOX_SCHPO

dsRNA-binding domain-like

dsrm

224

14.82

Ribosomal_S5

81

4.837

4.85E-04

0.0347669

10

31

RNC_ECOLI

RS5_MICLU

NAD(P)-binding Rossmann-fold domains

3HCDH

87

9.522

malic

122

6.317

5.85E-04

0.03518803

12

43

ECHA_HUMAN

MAOX_MESCR

Defensin-like

toxin_4

19

3.047

Defensin_beta

34

3.301

3.51E-03

0.0353041

7

22

BD01_BOVIN

TXAB_ANTXA

4-helical cytokines

IL-6

10

4.675

IL10

34

1.59

4.76E-03

0.03538227

13

62

2ilk__

IL6_BOVIN

Carbohydrate-binding domain

Cohesin

51

4.853

CBD_2

64

7.432

1.04E-03

0.0375102

13

52

GUND_CLOCL

CBPA_CLOCL

P-loop containing nucleotide triphosphate hydrolases

adenylatekinase

143

6.163

UvrD-helicase

89

13.46

4.69E-04

0.03890542

12

42

KAD3_HUMAN

HELD_ECOLI

Actin-like ATPase domain

hexokinase

88

5.215

actin

597

3.03

2.47E-03

0.03902958

17

85

ACT_CRYPV

HXK_DEBOC

Ferritin-like

ferritin

109

5.866

FA_desaturase

144

9.513

7.06E-04

0.0393971

23

117

Q40879

FTN_ECOLI

Periplasmic binding protein-like II

Sulphate_bind

10

3.949

Porphobil_deam

53

5.989

1.71E-03

0.04044246

16

75

SUBI_SYNP7

HEM3_HELPY

P-loop containing nucleotide triphosphate hydrolases

G-alpha

297

5.712

TK_herpes

77

6.72

1.09E-03

0.04183926

11

40

KITH_HSVMR

GB15_MOUSE

Viral coat and capsid proteins

Viral_coat

50

9.351

Tymo_coat

44

4.484

1.05E-03

0.04402638

19

92

COAT_TNVA

COAT_KYMVJ

Thiolase-like

Chal_stil_synt

225

2.472

ketoacyl-synt

348

11.05

1.68E-03

0.04589021

19

96

KAS1_STRHA

CHSB_PETHY

Thiamin diphosphate-binding fold (THDP-binding)

TPP_enzymes

165

13.78

POR_N

75

11.65

3.01E-04

0.04832164

19

83

O53182

ILVB_BACSU

Thiamin diphosphate-binding fold (THDP-binding)

TPP_enzymes

165

13.78

POR_N

75

11.65

3.01E-04

0.04832164

19

83

O53182

ILVB_BACSU

Glycosyltransferases

alpha-amylase

516

23.26

Glyco_hydro_14

31

3.376

6.19E-04

0.04860745

24

123

O23553

AMYM_BACST

NAD(P)-binding Rossmann-fold domains

3HCDH

87

9.522

adh_short

1018

14.91

4.13E-04

0.05863486

17

72

ECHP_RAT

HDHA_ECOLI

FAD/NAD(P)-binding domain

GDI

43

4.815

pyr_redox

447

18.96

6.58E-04

0.0600704

17

75

GSHR_PSEAE

Q21449

P-loop containing nucleotide triphosphate hydrolases

recA

235

2.294

PRK

51

8.268

3.18E-03

0.0603144

13

59

KPPR_SYNY3

RECA_AGRTU

P-loop containing nucleotide triphosphate hydrolases

UvrD-helicase

89

13.46

SRP54

128

8.144

5.79E-04

0.06346896

14

55

DOCK_SULAC

EX5B_ECOLI

Aldolase

DAHP_synth_1

21

3.172

F_bP_aldolase

52

6.595

3.04E-03

0.06359479

20

109

AROH_BUCAP

ALF_SCHPO

P-loop containing nucleotide triphosphate hydrolases

kinesin

314

7.939

SRP54

128

8.144

9.84E-04

0.06362073

14

58

U104_CAEEL

SRPR_CANFA

NAD(P)-binding Rossmann-fold domains

2-Hacid_DH

18

8.652

malic

122

6.317

1.18E-03

0.06460184

19

93

FDH_PICAN/93-310

MAOM_AMAHP/46-619

Homeodomain-like

homeobox

2390

6.356

HTH_2

45

14.74

7.04E-04

0.06595596

9

27

YA52_HAEIN

HME1_BRARE

(Phosphotyrosine protein) phosphatases II

Y_phosphatase

435

10.47

DSPc

96

11.23

6.20E-04

0.07289842

19

88

YB9T_YEAST

PTPM_MOUSE

NAD(P)-binding Rossmann-fold domains

GLFV_dehydrog

109

9.142

GFO_IDH_MocA

108

21.14

3.87E-04

0.07479235

15

59

STRI_STRGR

VDH_STRCO

Thioredoxin-like

glutaredoxin

63

10.09

thiored

475

12.78

5.92E-04

0.07633852

13

49

1jhb__

THI3_DICDI

Glucocorticoid receptor-like (DNA-binding domain)

LIM

655

12.16

GATA

184

4.428

1.42E-03

0.07645916

7

19

IS2A_ONCTS

SRD1_YEAST

alpha/beta-Hydrolases

abhydrolase

471

41.89

serine_carbpept

142

12.55

1.47E-04

0.07728077

30

153

1brob_

CBP2_WHEAT

Nucleotidylyl transferase

tRNA-synt_1c

92

10.9

tRNA-synt_1d

40

10.32

6.91E-04

0.07772921

24

124

SYR_MYCTU

SYE_HAEIN

Winged helix DNA-binding domain

HSF_DNA-bind

84

6.837

linker_histone

186

5.904

1.97E-03

0.07952033

7

20

HSF3_LYCPE

B4_XENLA

PLP-dependent transferases

aminotran_1

310

13.68

SHMT

88

4.264

1.37E-03

0.07991418

28

161

ATTY_RHIME

GLYA_HYPME

Sugar phosphatases

inositol_P

149

11.4

FBPase

79

4.226

1.72E-03

0.08286341

17

82

SUHB_ECOLI

F16R_RHOSH

Immunoglobulin

Filamin

317

12.22

TIG

259

21.67

3.33E-04

0.08818086

11

35

ABP2_HUMAN

Q00876

Fibronectin type III

Tissue_fac

11

5.151

fn3

2814

25.68

6.95E-04

0.09193299

14

56

TF_MOUSE

FINC_BOVIN

NAD(P)-binding Rossmann-fold domains

malic

122

6.317

GFO_IDH_MocA

108

21.14

7.00E-04

0.09347897

11

38

YDGJ_ECOLI

MAOX_MESCR

PapD-like

pili_assembly

57

7.15

MSP_domain

121

15.96

8.29E-04

0.09460051

14

57

O76615

CS31_ECOLI

Metalloproteases (""zincins""),catalytic domain

Peptidase_M8

50

3.615

Reprolysin

178

10.61

2.47E-03

0.09473722

14

64

Q27673

HR2_TRIFL

ConA-like lectins/glucanases

Glyco_hydro_16

108

10.13

pentaxin

57

4.971

1.95E-03

0.09819465

16

76

GUB_CLOTM

CRP_HUMAN

alpha/beta-Hydrolases

DLH

56

14.28

abhydrolase

471

41.89

1.65E-04

0.09870122

25

119

TFE2_ALCEU

XYLF_PSEPU

Winged helix DNA-binding domain

HTH_5

100

13.11

linker_histone

186

5.904

1.31E-03

0.10139589

12

47

O28708

H101_CHICK

Cyclin-like

transcript_fac2

74

8.877

RB_B

25

4.763

2.47E-03

0.10443444

14

64

O22346

TF2B_DROME

Ferritin-like

Bacteriofer

9

3.352

ribonuc_red

15

8.545

3.68E-03

0.10526244

20

111

BFR_MYCAV/1-154

RIR2_ECOLI/48-356

Tetrahydrobiopterin biosynthesis enzymes-like

GTP_cyclohydroI

42

3.79

PTPS

24

6.757

4.18E-03

0.10704575

13

61

GCH1_CHICK

PTPS_DROME

Arginase/deacetylase

arginase

57

10.07

Hist_deacetyl

90

8.758

1.25E-03

0.11024133

22

115

YB94_METTH

HUTG_BACSU

alpha/beta-Hydrolases

Peptidase_S9

85

7.898

serine_carbpept

142

12.55

1.12E-03

0.11101429

25

136

1qfsa2

CBP1_HORVU

Periplasmic binding protein-like II

SBP_bac_3

96

15.96

Porphobil_deam

53

5.989

1.33E-03

0.12712731

17

80

ARGT_ECOLI

HEM3_METJA

FKBP-like

FKBP

307

8.072

Rotamase

41

8.075

1.98E-03

0.12905917

11

43

SURA_ECOLI

FKBZ_PSEAE

alpha/beta-Hydrolases

Lipase_3

42

11.92

abhydrolase

471

41.89

2.59E-04

0.12932616

16

63

Q02351

BIOH_ECOLI

Thiamin diphosphate-binding fold (THDP-binding)

transketolase

87

6.031

POR_N

75

11.65

1.95E-03

0.13700924

17

83

O53182

TKT_RHOSH

DEATH domain

DED

57

6.602

death

98

12.9

1.64E-03

0.13967191

10

36

O35707

NGFR_RAT

PLP-dependent transferases

aminotran_2

124

13.65

Beta_elim_lyase

15

2.951

3.49E-03

0.14058121

27

165

HIS8_BACSU

TNAA_ECOLI

NAD(P)-binding Rossmann-fold domains

3HCDH

87

9.522

Epimerase

240

10.86

1.44E-03

0.14890884

15

67

HBD_CLOAB

RFBB_NEIGO

Periplasmic binding protein-like II

Porphobil_deam

53

5.989

lig_chan

168

7.97

3.18E-03

0.15178881

13

59

NME1_MOUSE

HEM3_PSEAE

Class II aaRS and biotin synthetases

tRNA-synt_2

118

11.83

tRNA-synt_2b

179

29.41

4.43E-04

0.15412869

23

113

SYT2_BACSU

SYK_THETH

Class II aaRS and biotin synthetases

tRNA-synt_2b

179

29.41

tRNA-synt_2d

51

8.578

6.30E-04

0.15893576

23

116

SYTM_YEAST

SYF_SULSO

N-terminal nucleophile aminohydrolases (Ntn hydrolases)

GATase_2

159

9.073

proteasome

301

12.25

1.44E-03

0.16004772

15

67

PRCZ_HUMAN

PUR1_YEAST

Nucleotidylyl transferase

tRNA-synt_1

178

17.31

Cytidylyltransf

97

14.55

6.58E-04

0.16572421

15

62

CTPT_CAEEL

SYIP_STAAU

ETFP adenine nucleotide-binding domain-like

Usp

75

17.03

ETF_alpha

31

6.908

1.42E-03

0.1670534

7

19

YDAA_HAEIN

ETFA_BRAJA

Nucleic acid-binding proteins

SSB

76

7.949

CSD

210

5.598

3.77E-03

0.16775935

9

34

O69302

CSP2_LACPL

Winged helix DNA-binding domain

linker_histone

186

5.904

trans_reg_C

262

9.048

3.59E-03

0.19177562

10

40

BAER_ECOLI

H1_YEAST

Metalloproteases (""zincins""),catalytic domain

Peptidase_M10

141

5.502

Reprolysin

178

10.61

3.33E-03

0.19439281

18

95

1slm__

ADAM_CROAD

Ferritin-like

ribonuc_red

106

8.545

FA_desaturase

144

9.513

2.51E-03

0.20403435

25

145

P92933

RIR2_BPT4

PLP-dependent transferases

aminotran_1

310

13.68

aminotran_5

140

19.29

7.89E-04

0.208207

23

118

1A14_LYCES

NIFS_BACSU

Zn-dependent exopeptidases

Peptidase_M17

52

6.289

Zn_carbOpept

174

12.14

2.77E-03

0.21148523

17

86

AMPL_ARATH

CBPN_HUMAN

Thioredoxin-like

GSHPx

83

4.06

thiored

475

12.78

4.56E-03

0.23660381

9

35

GSHG_HUMAN

THIO_ECOLI

Homeodomain-like

homeobox

2390

6.356

myb_DNA-binding

887

10.14

3.77E-03

0.2429759

9

34

Q60974

HX11_HUMAN

Ribulose-phoshate binding barrel

IGPS

82

5.938

PRAI

67

9.658

4.71E-03

0.27011475

14

69

TRPC_SULSO

TRPF_METTM

(Phosphotyrosine protein) phosphatases II

Rhodanese

187

20.13

DSPc

96

11.23

1.36E-03

0.30744146

8

24

YQHL_BACSU

PTP2_NPVOP

ATPase domain of HSP9

DNA_mis_repair

46

11.29

signal

517

18.21

1.57E-03

0.32277771

9

30

ATOS_ECOLI

MUTL_ECOLI

Globin-like

globin

1089

11.05

Phycobilisome

219

6.37

4.76E-03

0.33504926

13

62

PHAB_AGLNE

MYG_GALAU

DNA breaking-rejoining enzymes

Topoisomerase_I

28

3.71

Phage_integrase

273

25.43

3.57E-03

0.33681272

16

81

TOP1_SCHPO

XERD_HAEIN

PLP-dependent transferases

aminotran_1

310

13.68

OKR_DC_1

21

6.05

4.23E-03

0.35009172

22

128

DCOR_ECOLI

AAT1_MEDSA

alpha/beta-Hydrolases

COesterase

410

13.62

abhydrolase

471

41.89

6.30E-04

0.35944133

23

116

1brob_

ESTJ_HELVI

Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin

LTP

202

8.188

tryp_alpha_amyl

232

9.791

4.54E-03

0.36396593

7

23

IA01_WHEAT

NLTB_RICCO

Pectin lyase-like

Glyco_hydro_28

177

9.655

pec_lyase

89

8.892

4.67E-03

0.40093005

19

106

PEL_LILLO

PGLR_PERAE

S-adenosyl-L-methionine-dependent methyltransferases

DNA_methylase

263

14.43

N6_N4_Mtase

91

18.59

1.51E-03

0.40506309

17

81

1boo__

MTDX_HAEIN

Nucleotidylyl transferase

tRNA-synt_1

178

17.31

tRNA-synt_1d

40

10.32

2.55E-03

0.45552996

26

153

SYR_MYCLE

SYV_YEAST

S-adenosyl-L-methionine-dependent methyltransferases

CheR

31

8.951

N6_N4_Mtase

91

18.59

2.82E-03

0.46924543

11

45

1boo__

Q51346

PLP-dependent transferases

Cys_Met_Meta_PP

88

8.039

aminotran_3

213

11.85

4.95E-03

0.47154764

27

170

O02215

OAT_PLAFA

Glycosyltransferases

Glyco_hydro_2

47

8.302

alpha-amylase

516

23.26

2.77E-03

0.53489952

17

86

CDAS_THEET

BGLR_HUMAN

Glycosyltransferases

Glyco_hydro_2

47

8.302

alpha-amylase

516

23.26

2.77E-03

0.53489952

17

86

CDAS_THEET

BGLR_HUMAN

Nucleotidylyl transferase

tRNA-synt_1

178

17.31

tRNA-synt_1b

96

12.53

2.70E-03

0.58561461

18

93

SYY_ECOLI

SYI_ECOLI

Thioredoxin-like

GST

490

25.12

thiored

475

12.78

2.03E-03

0.65169821

10

37

ER72_RAT

GTT1_DROER

Zn-dependent exopeptidases

Peptidase_M17

52

6.289

Peptidase_M20

158

26.36

4.08E-03

0.6763744

18

97

O32106

O34984

Periplasmic binding protein-like II

Porphobil_deam

53

5.989

SBP_bac_5

237

25.58

4.71E-03

0.7215655

14

69

HBPA_HAEIN

Q49808

Periplasmic binding protein-like II

SBP_bac_3

96

15.96

SBP_bac_5

237

25.58

2.83E-03

1.15536674

14

65

NIKA_ECOLI

PEB1_CAMJE

Glycosyltransferases

cellulase

156

20.92

alpha-amylase

516

23.26

3.19E-03

1.55225145

19

102

GUN_PAEPO

TREC_ECOLI